Over 210 peer-reviewed publications, 14 active NIH grants, and a $62M research portfolio — advancing every dimension of male gestational science.
MRMP research spans six interconnected domains, from organoid bioengineering through postpartum endocrinology. Our labs collaborate closely, and many of our most significant advances have emerged at the intersection of disciplines.
The Zhao Laboratory focuses on the design, cultivation, and vascularization of patient-specific uterine organoids. Current work targets angiogenic signaling pathways to reduce rejection risk and improve long-term organoid function.
Dr. Zhao, PINIH R01 FundedResearch into optimizing induced pluripotent stem cell derivation from male somatic cells, with a focus on reducing epigenetic drift and improving the fidelity of gestational tissue differentiation.
Dr. Vasquez, PIHHMI FundedHormonal priming and gestational support protocols, including novel progesterone analogue regimens that have reduced premature organoid detachment by 28% in our most recent cohort.
Dr. Voss, PINIH R01 FundedDevelopment and refinement of minimally invasive implantation and delivery procedures, including the MRMP-developed laparoscopic organoid positioning system (LOPS) now in Phase II evaluation.
Dr. Okonkwo, PINIH R01 FundedExpanded preconception carrier screening panels, NIPT protocol adaptation for male gestational pregnancies, and research into epigenetic influences on offspring development and long-term health.
Dr. Park, PIGates FoundationLongitudinal study of psychological outcomes, identity formation, and family dynamics among MRMP patients and their partners. First multi-site dataset of its kind, with 8-year follow-up data now available.
Dr. Lindqvist, PINIH R01 FundedThe MRMP currently operates six IRB-approved clinical trials open to participant enrollment. All trials are registered at ClinicalTrials.gov.
| Study Title | Phase | PI | Status | NCT # |
|---|---|---|---|---|
| HUOI-Flex: Non-surgical Organoid Delivery System | Phase I | Dr. Zhao | Enrolling | NCT04881923 |
| TAD-EXTEND: Long-term Safety of Transanal Assisted Delivery | Phase III | Dr. Ferrara | Enrolling | NCT05124477 |
| PROGEX-2: Novel Progesterone Analogue in Male Gestation | Phase II | Dr. Voss | Enrolling | NCT04996102 |
| GENOME-MRMP: Epigenetic Profiles in Offspring at Age 5 | Observational | Dr. Park | Active, Not Enrolling | NCT04312850 |
| PSYCH-LONG: 8-Year Psychosocial Outcomes Registry | Observational | Dr. Lindqvist | Active, Not Enrolling | NCT04015678 |
| STEM-OPTIM: iPSC Reprogramming Efficiency in Male Donors | Phase II | Dr. Vasquez | Enrolling | NCT05402911 |
A selection of recent high-impact publications from MRMP investigators. View the full publications list →