A detailed, step-by-step guide to the MRMP clinical experience — from initial screening through postpartum recovery.
The MRMP offers three evidence-based insemination pathways. Your reproductive endocrinologist will discuss each option with you during care planning, and the final selection is always yours.
Processed sperm is introduced directly into the organoid cavity via a thin catheter guided by ultrasound. IUI is the simplest insemination procedure and is recommended for patients with favorable sperm parameters and no significant barriers to fertilization. Multiple cycles may be attempted.
Most CommonEggs (from a donor or partner) are fertilized with sperm in the laboratory to create embryos, which are then transferred into the organoid. IVF-ET is recommended when IUI has been unsuccessful or when genetic preimplantation testing (PGT) is desired. Offers the highest per-cycle success rates.
Highest Success RateConception occurs through natural intercourse prior to embryo transfer to the organoid. NI is available to patients who meet specific hormonal and timing criteria and prefer this approach. Conceived embryos are confirmed via early monitoring and subsequently transferred to the organoid under ultrasound guidance at the appropriate developmental stage.
Available for Eligible PatientsComplete the online pre-screening questionnaire. Schedule and attend a 60-minute initial consultation with a reproductive endocrinologist. No charge, no commitment required.
MRI abdomen/pelvis, full hormone panel, CBC, metabolic panel, genetic carrier screening (expanded 500-gene panel), psychological readiness assessment, and surgical consult with Dr. Okonkwo's team.
Your multidisciplinary team meets to review all findings. Acceptance decision communicated. Accepted patients complete enrollment paperwork, meet their Patient Navigator, and select insemination and delivery pathways.
Outpatient skin biopsy (15 minutes) under local anesthesia. Cells are delivered to the Zhao Laboratory for iPSC reprogramming. Most patients return to normal activity the same day.
The Zhao Laboratory cultivates your patient-specific gestational organoid. You receive weekly status updates via secure message. Milestone reports are sent at weeks 10, 14, and 18.
A structured 4–6 week hormonal regimen prepares the peritoneal environment for organoid acceptance. Estrogen and progesterone protocols are managed by Dr. Voss's team with weekly monitoring labs.
Laparoscopic organoid implantation performed by Dr. Okonkwo's team. Typically 90 minutes; one overnight observation stay. Imaging confirmation at weeks 27 and 31 post-enrollment.
Biweekly imaging and hormonal monitoring to confirm organoid vascularization and functional readiness. Full readiness is typically confirmed at 8 weeks post-implantation.
IUI, IVF-ET, or NI procedure performed per your selected pathway. Pregnancy confirmed by hCG monitoring at 2 and 4 weeks post-procedure.
Full-term gestation of approximately 39 weeks. Biweekly MRMP prenatal visits with ultrasound, hormonal management, nutritional guidance, and behavioral health support throughout.
Delivery planning meeting at week 34 of gestation. Scheduled delivery at 37–39 weeks via your chosen pathway (CE or TAD) at Harrington University Medical Center.
Comprehensive postpartum program including hormonal tapering, surgical follow-up, lactation consultation, psychological support, and pediatric coordination. Formal program discharge at 12 months post-delivery.